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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: Local delivery of USC-derived exosomes harboring ANGPTL3 enhances spinal cord functional recovery after injury by promoting angiogenesis

Fig. 9

Schematic diagram showing the role of exosomal ANGPTL3 from human USC-derived exosomes in mediating the protective effect on functional recovery after spinal cord injury by promoting angiogenesis. USC-derived exosomes enriched with ANGPTL3 and are imbedded in hydrogel and used to cover the injured spinal cord surface. The exosomes can cross the spinal cord blood-brain barrier (BBB) and be taken up by spinal cord microvasculature endothelial cells, where ANGPTL3 induces PI3K and AKT phosphorylation and subsequently promotes angiogenesis

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Stem Cell Research & Therapy

ISSN: 1757-6512