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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Improvement of the therapeutic capacity of insulin-producing cells trans-differentiated from human liver cells using engineered cell sheet

Fig. 6

a Levels of liver toxicity. Normal mice, diabetic controls, and mice injected with phosphate-buffered saline via the portal vein did not show increased serum aspartate aminotransferase (AST) and alkaline aminotransferase (ALT). AST and ALT levels rapidly increased after injection of insulin-producing cells (IPCs) and transplantation of IPC sheets at day 1 and recovered to baseline levels after 5 days. AST and ALT levels of mice injected with IPCs were higher than in mice transplanted with IPC sheets. b One and 2 weeks after IPC sheet transplantation or IPC injection, the liver was observed macroscopically. The dotted line indicates the necrotic area. c One and 2 weeks after transplantation, the livers of both groups were analyzed by hematoxylin and eosin staining. The dotted line indicates the necrotic area, and solid line indicates the sheet-transplanted area on the liver surface

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