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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: microRNA-186 in extracellular vesicles from bone marrow mesenchymal stem cells alleviates idiopathic pulmonary fibrosis via interaction with SOX4 and DKK1

Fig. 6

EV-miR-186 alleviates PF in vivo. a Hydroxyproline content in the lung tissues of mice. b miR-186 expression in the lung tissues of mice determined by RT-qPCR. ce The protein expression of SOX4 and DKK1 in the lung tissues of mice determined by Western blot analysis. f The protein expression of α-SMA and collagen I in the lung tissues of mice measured by Western blot analysis. *p < 0.05 vs. the sham-operated mice; #p < 0.05 vs. the mice with PF; &p < 0.05 vs. the mice with PF treated with EVs from inhibitor NC-transfected BMSCs. Differences among groups were determined by one-way ANOVA, N = 8

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