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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Intramuscular injection of Botox causes tendon atrophy by induction of senescence of tendon-derived stem cells

Fig. 4

a Gross observation of pellet culture for chondrogenesis of TDSCs in the Botox and control group showing the larger size of the pellet culture system from control. b H&E staining of pellet culture in Botox and control group showed better cell population in the control compared to the Botox group. c Safranin-O staining of the pellet culture system demonstrated greater proteoglycan deposition in control. d mRNA expression of chondrogenic differentiation markers (Aggrecan and SOX9) in the control and Botox group. Individual mRNA expression levels were first normalised to internal control (36B4) and then normalised against mRNA expression level from the control group (n = 3; mean ± SD; ***p < 0.001)

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Stem Cell Research & Therapy

ISSN: 1757-6512