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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: The therapeutic efficacy of mesenchymal stromal cells on experimental colitis was improved by the IFN-γ and poly(I:C) priming through promoting the expression of indoleamine 2,3-dioxygenase

Fig. 1

The IFN-γ and poly(I:C)-primed MSCs were more effective than were unstimulated MSCs in ameliorating the DSS-induced colitis in mice. a Experimental outline. 2.5% DSS was given to B6 mice via drinking water for 5 days to induce colitis. The primed or unstimulated MSCs were injected i.p. to mice on days 1 and 3. All mice were sacrificed on day 9 to harvest the spleen, mLN, and colon tissues. Results are combined from two independent experiments. b Daily body weight (normal, n = 4; other groups, n = 9). c Daily DAI score (DSS vs. DSS + primed MSC, *p < 0.05, **p < 0.01, ***p < 0.001; DSS + MSC vs. DSS + primed MSC, #p < 0.05, ##p < 0.01, ###p < 0.001). d Colon lengths. e H&E-stained images of colon sections, representative data of two independent experiments, are shown (normal, n = 3; other groups, n = 4). The primed MSCs significantly reduced the pathologic scores (*p < 0.05, **p < 0.01, ***p < 0.001)

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