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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Human umbilical cord mesenchymal stem cell-derived extracellular vesicles ameliorate airway inflammation in a rat model of chronic obstructive pulmonary disease (COPD)

Fig. 5

Airway and parenchyma inflammation in the injury and treatment groups. Histological image of peribronchial (a). The histological image of parenchyma (b). Semi-quantitative histological scoring and analysis of airway inflammation (c). Lung parenchymal inflammation (d). The arrow on a showed accumulation of immune cells in the peribronchial area when exposed to CS for 12 weeks, and self-healing for 2 weeks did not reduce the inflammation. The arrow on b showed accumulation of immune cells in the parenchyma area, while 2 weeks of self-healing (CSSH group) did not reduce the inflammation. The scores for inflammation in the airway and alveolar area significantly reduced following treatment with UCMSC-EVs, hUC-MSCs, and hUC-MSC-CM (****p < 0.0001) compared to the CS group

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Stem Cell Research & Therapy

ISSN: 1757-6512