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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Persistence of intramyocardially transplanted murine induced pluripotent stem cell-derived cardiomyocytes from different developmental stages

Fig. 4

Cell persistence after transplantation of iPSC-CM in infarcted mouse hearts. a Representative image of eGFP-positive iPSC-CM within a ventricular slice of the recipient heart, 7 days after transplantation. Left scale bar 1 mm, right scale bar 100 μm. b Number of iPSC-CM assessed by qPCR 6–7 days after injecting 2 × 500,000 iPSC-CM in the infarct border zone. iPSC-CM were transplanted at 14 or 16 days after starting the differentiation process. Mean persistence was approximately 7-fold higher in cells transplanted at day 14 of differentiation compared to day 16 iPSC-CM. Statistical analysis was performed using the Mann–Whitney rank sum test, p < 0.001

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