Fig. 8
From: Exosomal microRNA-22-3p alleviates cerebral ischemic injury by modulating KDM6B/BMP2/BMF axis
Molecular schematic diagram concerning EV-miR-22-3p in cerebral ischemic injury. ASC-EVs could alleviate cerebral ischemic injury, where miR-22-3p was enriched in ASC-EVs. ASC-EV-miR-22-3p targeted and inhibited KDM6B expression, suppressing the binding between KDM6B and BMP2, and the decreased KDM6B downregulated BMF through the inhibition of BMP2 expression. Thereby, ASC-EV-miR-22-3p attenuates cerebral ischemic injury by suppressing KDM6B-mediated effects on the BMF/BMP2 axis