Skip to main content
Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Bleomycin induces fibrotic transformation of bone marrow stromal cells to treat height loss of intervertebral disc through the TGFβR1/Smad2/3 pathway

Fig. 7

Regulatory function of bleomycin in the fibroblastization of BMSCs in the microenvironment of the nucleus pulposus. Bleomycin could induce the fibroblastization of BMSCs; it promotes the fibroblastic transformation of AF cells by increasing the expression of TGFβ and TGFβR1, which activates the TGFβ/Smad2,3 signaling pathway, and finally by increasing the proliferation and migration of these cells. On the other hand, it could stimulate the NP cells to secrete MMP3 and MMP13 to remodel the ECM in the NP that is beneficial for the migration of fibroblastic cells. Locally, injection of bleomycin would increase the Col1a1 and Col3a1 then finally lead to accelerated reparative fibrosis

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512