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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Human amnion-derived mesenchymal stem cells promote osteogenic differentiation of lipopolysaccharide-induced human bone marrow mesenchymal stem cells via ANRIL/miR-125a/APC axis

Fig. 3

LncRNA-ANRIL in HBMSCs inhibited osteogenesis in vivo. a The cells in the NC, ANRIL, shNC, and shANRIL groups were transplanted subcutaneously into a rat critical-sized mandibular defect model. b Reconstructed 3D micro-CT images of the tissue-engineered bone and values of BV/TV. c H&E staining, Masson staining, and immunohistochemical staining of RUNX2 in each group (b: bone-like tissues; h: HA/TCP scaffold; f: fibrous). Scale bar, 200 μm. Data are represented as mean ± standard error of the mean for both groups. *P < 0.05 and **P < 0.01. NC: HAMSCs + LPS + HBMSCsNC; ANRIL: HAMSCs + LPS + HBMSCsANRIL; shNC: HAMSCs + LPS + HBMSCsshNC; shANRIL: HAMSCs + LPS + HBMSCsshANRIL

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