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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Infrapatellar fat pad-derived mesenchymal stem cell-based spheroids enhance their therapeutic efficacy to reverse synovitis and fat pad fibrosis

Fig. 2

Molecular and secretory profiling of 2D IFP-MSC and IFP-MSC spheroids. a Molecular profiling of non-induced IFP-MSC spheroids versus non-induced 2D IFP-MSC cultures revealed that 49 out of 90 genes tested were higher expressed in IFP-MSC spheroids with 24 genes being more than twofold higher. Genes tested were grouped in phenotype/function-related cohorts. b, c The secretory profile of inflammation-related cytokines revealed that non-induced IFP-MSC spheroids show significantly (p < 0.05) higher secretion of 13 and lower secretion of 5 (IL-6, IL-6sR, IL-16, MIP-1-β, TNF-α) out of 40 secreted proteins tested compared to naïve 2D IFP-MSC cultures. In addition, non-induced IFP-MSC spheroids show significantly (p < 0.05) higher secretion of 36 out of 41 secreted protein tested. Heat maps’ colors are assigned according to a molecule concentration relative scale, from 0 to 10,000. All experiments were performed independently (n = 2)

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