Fig. 5
MSC treatment (5 × 105) improves hind limb ischemia. BM-MSC-treated mice indicated accelerated functional recovery according to Tarlov score at days 14, 21, and 28 (p <  0.0001 for all time points) and Function score at days 3 and 28 (p = 0.0004, p = 0.01) (a, b). BM-MSC-treated mice had greater improvement of ischemia compared with the control group as shown by ischemia score at day 21 (p = 0.02), modified ischemia score at day 7 (p = 0.01) (c, d). BM-MSCs and AT-MSCs had similar effect on improvement of necrotic changes according to the grade of limb necrosis score at day 7 (p = 0.02) (e)