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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Intraperitoneal injection of Desferal® alleviated the age-related bone loss and senescence of bone marrow stromal cells in rats

Fig. 1

micro-CT analysis of rat femur following intraperitoneal injection of Desferal®. a Schema of long-term Desferal administration of the in vivo study. b Representative three-dimensional micro-CT images of femurs in 2M, 12M-VEH, 12M-L-Desferal® (20 mg/kg), and 12M-H-Desferal® (60 mg/kg) groups. Bar = 1 mm. c Quantification of bone morphometric parameters of rat femur by micro-CT analysis. Significantly increased BV/TV, Tb.N and Coon.D and decreased Tb.Sp and SMI were observed in the 12M-H-Desferal® group when related to those of the 12M-VEH group. All of these parameters were statistically significant between the 2M and 12M-VEH groups. After Desferal® treatment, especially in the 12M-H-Desferal® group, bone mass increased significantly.BV/TV, bone volume/total volume; Tb.N, trabecular number; Tb.Th, trabecular thickness; Coon.D, trabecular connectivity density; Tb.Sp, trabecular separation; SMI, structural model index. *p < 0.05, **p < 0.01, ***p < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512