Donor heart preservation with hypoxic-conditioned medium-derived from bone marrow mesenchymal stem cells improves cardiac function in a heart transplantation model

Table 1 Differentially secreted cytokines levels between hypoxic and normoxic CdM-BMSCs measured by antibody array

Protein name	EntrezID	Hypoxic CdM mean ± SD	Normoxic CdM mean ± SD	Fold change hypoxic/normoxic	p value
Decorin	29139	10,299.06 ± 2918.47	5285.78 ± 157.00	1.901	0.041
CINC-2	171551	96,123.26 ± 9191.66	57,240.66 ± 10,395.19	1.692	0.008
PDGF-AA	25266	250,149.29 ± 24,866.75	153,260.81 ± 43,629.50	1.668	0.029
Neuropilin-2	81527	5556.21 ± 880.88	3613.78 ± 309.85	1.529	0.023
Activin A	29200	10,671.66 ± 987.40	7238.02 ± 1275.96	1.486	0.021
b-NGF	310738	23,323.71 ± 2472.75	16,720.57 ± 1002.78	1.391	0.013
IL-6	24498	661.95 ± 74.93	497.30 ± 33.82	1.327	0.026
VEGF	83785	246,817.39 ± 15,669.76	198,745.19 ± 16,099.43	1.243	0.021
Flt-3 L	103691134	915.92 ± 9.66	757.78 ± 22.63	1.209	0.0004
IL-10	25325	1824.10 ± 59.43	2406.64 ± 264.84	0.761	0.021
IL-13	116553	818.78 ± 205.59	1273.62 ± 57.60	0.630	0.021
CINC-1	81503	12,568.68 ± 4510.34	24,729.04 ± 2903.48	0.488	0.017

Significantly altered proteins listed first with a p value for the fold change. Data represent mean ± standard deviation (SD) (n = 3/group). T test/Mann-Whitney was applied in statistical analysis
CdM conditioned medium, CdM-BMSCs conditioned medium-derived from bone marrow mesenchymal stem cells

ISSN: 1757-6512