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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Human foreskin-derived dermal stem/progenitor cell-conditioned medium combined with hyaluronic acid promotes extracellular matrix regeneration in diabetic wounds

Fig. 4

The effect of hFDSPCs on inflammation in wound of db/db mice was evaluated via optical microscopy analysis. a Re-epithelialisation on day 14 was analysed using H&E staining in wound tissue sections, and photos were taken with a × 1.25 lens. b Re-epithelialisation is indicated by the yellow dotted line, bar = 400 μm. c CD31-stained wound tissues on day 14 were shown via IHC assay, bar = 200 μm. d Statistical analysis of number of CD31-positive vessels in the wound tissues. e CD68 staining results showed infiltration of macrophages/monocytes on day 14, and the black arrows indicate accumulation of CD68-positive cells in wound tissues, bar = 100 μm. f The number of CD68-positive cells on day 14 was counted. CD86 (g) (red) and CD206 (i) (red) staining results showed M1 or M2 type macrophage polarisation on day 14. The number of CD86- (h) and CD206- (j) positive cells on day 14 was counted, bar = 100 μm. Data are shown as means ± SD; n = 5; *p < 0.05, **p < 0.01, ***p < 0.001

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