Fig. 5
Retinal appearances during the study period. A1 Fundus montages demonstrate generalized pigmentary changes with heavy bone spicules and macular involvement. A2 and A3 images, representing months 6 and 12, respectively, show similar appearances. B1 Fundus autofluorescence images describe the central hyper-autofluorescence surrounding the island of hypo-autofluorescence in the macula, where autofluorescence indicates the presence of normal retinal pigment epithelium (RPE). B2 and B3 images represent months 6 and 12, respectively, with no remarkable changes. C1, C2, C3 The optical coherence tomography indicates central subfield thickness at baseline, month 6, and month 12, respectively. The study eye and fellow eye show similar appearances. Images were retrieved from a study participant in group 1