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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Improvement of sensory neuron growth and survival via negatively regulating PTEN by miR-21-5p-contained small extracellular vesicles from skin precursor-derived Schwann cells

Fig. 3

Effect of medium dose of SKP-SC-EVs on growth of DRGs and sensory neurons (see also Additional file 2: Figure S1). a Representative image of axonal outgrowth of TUJ1 positive (green) DRG explants after vehicle (Control) or EV treatment during 5 days. Scale bar, 500 μm. b TUJ1 (green) positive sensory neurons showing neurite growth after treatment with EVs for 12 h. Scale bar, 20 μm. c Histograms showing the increasing axonal area of DRGs in the EV groups. n = 5; *p < 0.05, **p < 0.01 compared with the vehicle group. d Histograms showing the longer neurite length of sensory neurons treated with EVs. ***p < 0.001 compared with the vehicle group

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Stem Cell Research & Therapy

ISSN: 1757-6512