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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: CAR T cells in solid tumors: challenges and opportunities

Fig. 1

CAR T cell engineering. The design of the CAR T cell has evolved by combining existing immune cell components to facilitate direct targeting of tumor antigens. scFv of CAR-induced light and heavy chains of the antibody variable region, whereas the CAR amplitude CD3ζ has been derived from the intracellular signaling domains of the TCR

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