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Table 1 Most targeted antigen in clinical trials in solid tumor CAR T cell therapy

From: CAR T cells in solid tumors: challenges and opportunities

Antigen Cancer Phase ID
EGFR Lung, liver, stomach Phase 1/2 NCT03179007, NCT03525782
HER2 Central nervous system tumor, pediatric glioma Phase 1 NCT03500991
EGFR806 Central nervous system tumor, pediatric glioma Phase 1 NCT03179012
Mesothelin Ovarian, cervical, pancreatic, lung Phase 1/2 NCT01583686
PSCA Lung Phase 1 NCT03198052
MUC1 Advanced solid tumors, lung Phase 1/2 NCT03179007, NCT03525782
Claudin 18.2 Advanced solid tumor Phase 1 NCT03874897
EpCAM Colon, pancreatic, prostate, gastric, liver Phase 1/2 NCT03013712
GD2 Brain Phase 1 NCT04099797
VEGFR2 Melanoma, brain Phase 1 NCT01218867
AFP Hepatocellular carcinoma liver cancer Phase 1 NCT03349255
Nectin4/FAP Nectin4-positive advanced malignant solid tumor Phase 1 NCT03932565
CEA Lung, colorectal, gastric, breast, pancreatic cancer Phase 1 NCT02349724
Lewis Y Advanced cancer Phase 1 NCT03851146
Glypican-3 Liver Phase 1 NCT02932956
EGFRIII Glioblastoma and brain tumor Phase 1 NCT01454596
IL-13Rα2 Glioblastoma Phase 1 NCT02208362
CD171 Neuroblastoma Phase 1 NCT02311621
MUC16 Ovarian Phase 1 NCT02311621
PSMA Prostate Phase 1 NCT01140373
AFP Hepatocellular carcinoma, liver Phase 1 NCT03349255
AXL Renal Phase 1 NCT03393936
CD20 Melanoma Phase 1 NCT03893019
CD80/86 Lung Phase 1 NCT03198052
c-MET Breast, hepatocellular Phase 1 NCT03060356, NCT03638206
DLL-3 Lung Phase 1 NCT03392064
DR5 Hepatoma Phase 1 NCT03638206
EpHA2 Glioma Phase 1 NCT02575261
FR-α Ovarian Phase 1 NCT00019136
gp100 Melanoma Phase 1 NCT03649529
MAGE-A1/3/4 Lung Phase 1 NCT03356808, NCT03535246
LMP1 Nasopharyngeal Phase 1 NCT02980315
  1. EGFR epidermal growth factor receptor, HER2 human epidermal growth factor receptor 2, PSCA prostate stem cell antigen, MUC1 mucin1, EpCAM epithelial cell adhesion molecule, AFP alpha-fetoprotein, FAP familial adenomatous polyposis, CEA carcinoembryonic antigen, MUC16 mucin16, PSMA prostate-specific membrane antigen, AXL AXL receptor tyrosine kinase, DLL3 delta-like 3, EPHA2 EPH receptor A2, FRα folate receptor alpha, LMP1 Epstein-Barr virus latent membrane protein 1, MAGE melanoma antigen gene protein, DR5 death receptor 5