Table 2 Currently active clinical trials exploring subconjunctival injection of MSCs for treating corneal epithelial damages
ClinicalTrials.gov identifier / Clinicaltrialsregister.eu identifier | Condition or disease | Cell administration | Study design | Number of patients | Sponsor and performing center | Status and initiation date |
|---|---|---|---|---|---|---|
NCT01808378 / EudraCT2010-024328-53 | Keratopathy associated with bilateral LSCD | Human autologous AT-MSCs: 4 injections (4 × 106 MSCs per quadrant) + topical application of 4 × 106 MSCs for 20 min + amniotic membrane | Interventional, phase 2, single arm, unmasked | 8 | Research Institute of La Paz University Hospital, Madrid, Spain | Completed according to clinicaltrialsregister.eu 2012 |
NCT02325843 | Corneal chemical burn | Human BM-MSCs: 1 injection of 5 × 106 MSCs/500 μl + amniotic membrane. If persistent epithelial defect was noted, a second injection was performed. | Interventional, phase 2, single arm, unmasked | 16 | Sun Yat-sen University, Guangzhou, China | Completed 2014 |
NCT04484402 | Corneal ulcer, corneal disease, corneal dystrophy | Autologous AT-MSCs + sodium hyaluronate 1% solution Autologous limbal stem cells + sodium hyaluronate 1% solution | Interventional, phase 1–2, three-arm parallel assignment, non-randomized, unmasked | 25 | Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus | Completed 2016 |
NCT03237442 | Corneal chemical burn | Human umbilical cord MSCs: 1 injection of 2 × 106 MSCs/200 μl | Interventional, phase 1–2, two-arm parallel assignment, randomized, double masked | 100 | Guangzhou Saliai Stem Cell Science and Technology Co. Ltd., China | Not yet recruiting (unknown status) 2017 |
NCT03967275 | Corneal chemical burn | Allogeneic human BM-MSCs | Observational, single arm | 3 | Ophthalmological Foundation Adolphe de Rothschild, Paris, France | Not yet recruiting 2019 |