Table 2 Characteristics of subcutaneous injections of ASCs embedded in scaffolds2
Author (year) | Type of scaffold | Subtype (intervention) | Specimens | ASCs | Gauge | Placement | ASCs/ml | Number |
|---|---|---|---|---|---|---|---|---|
Cai et al. (2015) [14] | Copolymer | aPEG with 1 wt% bPNIPAM (SHIELD-1) + ASCs | Athymic nude mice | Human | 28 G | Dorsum | 16,665,000 | 5 |
aPEG with 0.7 wt% bPNIPAM (SHIELD-0.7) + ASCs | ||||||||
aPEG with w/o bPNIPAM (SHIELD-0) + ASCs | ||||||||
Linh et al. (2017) [24] | cCHPA-dGTA-ePDGF-BB + ASCs | BALB/c nude mice | Human | NR | Dorsum | 10,000,000 | 4 | |
cCHPA-dGTA + ASCs | ||||||||
Chen et al. (2017) [18] | Copolymer + protein | Laminin-alginate beads + ASCs | Sprague-Dawley rats | Rats Autologous | NR | Dorsum | 50,000 | 3 |
Adipocytes + laminin-alginate beads + ASCs | ||||||||
Choi et al. (2006) [25] | Polymer | fPLGA + dASCs | Athymic nude mice | Human | 23 G | Neck | 1,000,000 | 6 |
Choi et al. (2009) [26] | ECM | Human ECM powder + ASCs | BALB/c mice | Human | 18 G | Dorsum | 1,000,000 | 10 |
Kim et al. (2012) [27] | Polysaccharide | Alginate + dASCs | Nude mice | Human | 23 G | Chest wall and abdomen | ~ 1,000,000 | 5 |
Cheung et al. (2013) [28] | gDAT + (GAG + polymer) or (polysaccharide + polymer) | hMGC + 5% gDAT + dASCs | Wistar rats | Human | NR | NR | ~ 1,000,000 | 3 |
iMCS + 5% gDAT + dASCs | ||||||||
Wang et al. (2013) [29] | ECM | jSISE + ASCs | Nude mice | Human | NR | Dorsum | 100,000 | 6 |
kATE + ASCs | ||||||||
Sumi et al. (2013) [19] | Protein + anticoagulant | lF/P, plasma, mFGF-2 and ASCs | Fischer 344 rats | Rats | 25 G | Dorsum | 4,000,000 | NR |
lF/P and plasma and ASCs | ||||||||
Plasma and mFGF-2 and ASCs | ||||||||
lF/P, serum and mFGF-2 and ASCs | ||||||||
lF/P and serum and ASCs | ||||||||
Serum and mFGF-2 and ASCs | ||||||||
Derby et al. (2014) [20] | Peptide | nPuraMatrix + ASCs | Nude mice | Murine | 23 G | Parascapular | 5,000,000 | 6 |