Differences of embedding adipose-derived stromal cells in natural and synthetic scaffolds for dermal and subcutaneous delivery

Table 6 Characteristics of subcutaneously implanted ASCs embedded in scaffolds4

Author (year)	Type	Subtype (intervention)	Specimen	ASCs	Placement	ASC/ml	Number
Wu et al. (2017) [33]	Biodegradable polymer	^aPLGA and ^bOEG₁ + ASCs	Nude mice	Huabman	Dorsum	500,000	14
Wu et al. (2017) [33]		^aPLGA and ^cOEG₉ + ASCs	Nude mice	Huabman	Dorsum	500,000	14
Zhang et al. (2017) [34]		^aPLGA + dASCs	Nude mice	Human	Dorsum	NR	5
Zhang et al. (2017) [34]		^aPLGA + ASCs	Nude mice	Human	Dorsum	NR	5
Cho et al. (2005) [35]		Fibrin gel, ^dbFGF + dASCs	Athymic nude mice	Human	Dorsum	80,000,000	4
Cho et al. (2005) [35]		Fibrin gel, ^dbFGF, ^ePGA + ^fPLLA + dASCs	Athymic nude mice	Human	Dorsum	80,000,000	4
Hong et al. (2006) [36]	Gelatin	Gelatin sponge + dASCs	SCID mice	Human	Dorsum	3,000,000	4
Hong et al. (2006) [36]	Gelatin	Gelatin sponge + ASCs	SCID mice	Human	Dorsum	3,000,000	4
Dhillon et al. (2019) [37]	Polysaccharide + peptide sequence	^gMGC + ASCs	NOD/SCID mice	Human	Dorsum	10,000,000	6
		^gMGC-^hRGD + ASCs
		^gMGC-ⁱIKVAV + ASCs
Jing et al. (2007) [23]	Polysaccharide	Alginate +ASCs	BALB/c mice	Murine	Dorsum	2,000,000	8
Jing et al. (2007) [23]	Polysaccharide	Alginate +dASCs	BALB/c mice	Murine	Dorsum	2,000,000	8
Storck et al. (2017) [38]	Biodegradable polymer and protein	^jPu-fibrin + ASCs	Athymic mice	Human	Groin	1,000,000	5
		^jPu-fibrin + dASCs
		^jPu-fibrin +dASCs + fat flap

dASCs adipogenically differentiated ASCs, ^aPLGA poly (lactide-co-glycolide), ^bOEG₁ ethylene glycol, ^cOEG₉ oligo (ethylene glycol) 400, ^dbFGF basic fibroblast growth factor, ^ePGA poly (glycolic acid), ^fPLLA poly(L-lactic acid), ^gMGC N-methacrylate glycol chitosan, ^hRGD GGGGRGDS peptide sequence derived from collagen and fibronectin, ⁱIKVAV CSRARKQAASIKVAVSADR peptide sequence derived from laminin, ^jPU poly(ε-caprolactone)-based polyurethane

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