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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: LncRNA-NEAT1 from the competing endogenous RNA network promotes cardioprotective efficacy of mesenchymal stem cell-derived exosomes induced by macrophage migration inhibitory factor via the miR-142-3p/FOXO1 signaling pathway

Fig. 5

ExosomeMIF conferred cardiac protection by targeting FOXO1. Cardiomyocytes were transfected with siRNA-FOXO1 or siRNA-NT control, treated with exosomeMIF, and subjected to H2O2. Cardiomyocytes with or without exosomeMIF were subjected to H2O2. Untreated cardiomyocytes were used as a control. (a) Representative distributions of propidium iodide and Annexin V staining from FACScan flow cytometric analyses of apoptotic cells. (b) Apoptotic cells in the above conditions. (c) Activities of caspases 3/7 and (d) caspase 8 in cell lysates were measured by ELISA. Each column represents mean ± SD of three independent experiments. *P < 0.05 vs. control; ▲P < 0.05 vs. H2O2; ○P < 0.05 vs. H2O2+exosomeMIF+siRNA-FOXO1.

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Stem Cell Research & Therapy

ISSN: 1757-6512