HMOX1 is partly responsible for phenotypic and functional abnormalities in mesenchymal stem cells/stromal cells from placenta of preeclampsia (PE) patients

Table 1 Differential gene expression in PE-DBMSCs as compared to normal DBMSCs

Decreased levels in PE-DBMSCs		Increased levels in PE-DBMSCs
Pro-inflammatory cytokines	Pro-inflammatory chemokines	Anti-inflammatory cytokines	Adhesion molecules
IL1A	CCL3	IL10	ITAG 1
IL1B	CCL17	IL19	ITAGA2B
IL6	CCL18	IL20	ITGB2
IL18	CCL24	IL22	ITGAX
1 L21	CCL27	IL10RA	PECAM
IL31	CXCL11	IL20RA
IL33

Abbreviations: DBMSCs decidua basalis mesenchymal stem cells, PE-DBMSCs preeclampsia decidua basalis mesenchymal stem/stromal cells, IL1A interleukin 1A, IL1B interleukin 1B, IL16 interleukin 16, IL18 interleukin 18, IL21 interleukin 21, IL21 interleukin 21, IL31 interleukin 31, IL33 interleukin 33, CCL3 chemokine (C-C motif) ligand 3, CCL17 chemokine (C-C motif) ligand 17, CCL18 chemokine (C-C motif) ligand 18, CCL24 chemokine (C-C motif) ligand 24, CCL27 chemokine (C-C motif) ligand 27, CXCL11 chemokine (C-X-C motif) ligand 11, IL10 interleukin 10, IL19 interleukin 19, IL20 interleukin 20, IL22 interleukin 22, IL10 RA interleukin 10 receptor alpha, IL20RA interleukin 20 receptor alpha, ITAG 1 integrin 1, ITAGA2B integrin alpha 2b, ITGB2 integrin beta 2, ITGAX integrin alpha X, PECAM platelet endothelial cell adhesion molecule

ISSN: 1757-6512