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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Umbilical cord-matrix stem cells induce the functional restoration of vascular endothelial cells and enhance skin wound healing in diabetic mice via the polarized macrophages

Fig. 7

PGE2 plays a role in the UCMSC-CM-induced functional recovery of diabetic vascular endothelial cells via remodeling of the macrophage phenotypes. High-glucose-induced HUVECs, which were indirectly cocultured with macrophages, were treated with NS-398-CM, a mixture of UCMSC-CM with an anti-PGE2 neutralizing antibody, or NCM plus PGE2. The functions of HUVECs were determined by angiogenesis assays, migration assays, and chemotaxis assays. a Representative images of the angiogenesis assay. Scale bar 200 μm. b Quantitative analysis of the total tube length in the angiogenesis assay. c Representative images of the migration assay. Scale bar 200 μm. d Quantitative analysis of the wound area in the migration assay. e Quantitative analysis of the chemotactic cell number in the chemotaxis assay. n = 6 per group. *P < 0.05, **P < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512