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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Mesenchymal stem cell-derived exosomes ameliorate cardiomyocyte apoptosis in hypoxic conditions through microRNA144 by targeting the PTEN/AKT pathway

Fig. 3

Mesenchymal stem cell-derived exosomes affected H9C2 cell apoptosis and p-AKT/AKT expression levels when cultured in hypoxic conditions. A1, A2 Increasing concentrations of exosomes had an effect on the amount of H9C2 cell apoptosis in hypoxic growth conditions. B1B3 Flow cytometry analysis showed that exosomes protected H9C2 cells from apoptosis in hypoxic growth conditions. C1C3 Exosomes regulated the expression levels of p-AKT and AKT in hypoxic growth conditions. ###P < 0.001 vs. normoxia; ##P < 0.01 vs. normoxia; ***P < 0.001 vs. hypoxia; **P < 0.01 vs. hypoxia. Exo, exosomes; p-AKT/AKT, phosphorylated protein kinase B. Statistics calculated based on the results of three repetitions of each experiment

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