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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Mesenchymal stem cell-derived exosomes ameliorate cardiomyocyte apoptosis in hypoxic conditions through microRNA144 by targeting the PTEN/AKT pathway

Fig. 4

MiR-144 modulates the effect of MSC-derived exosomes on H9C2 cell apoptosis and p-AKT/AKT expression levels. A The expression of miR-144 was significantly higher in MSC-derived exosomes than in MSCs. ###P < 0.001 vs. MSCs. B1B3 Transfection of H9C2 cells with a miR-144 inhibitor partially inhibited the protective effect of MSC-derived exosomes on cell apoptosis in the context of hypoxia. ###P < 0.001 vs. hypoxia; ***P < 0.001 vs. hypoxia+Exo. C1C3 Transfection of H9C2 cells with a miR-144 inhibitor modulated the effect of MSC-derived exosomes on changes in p-AKT/AKT expression levels in hypoxic conditions. ###P < 0.001 vs. hypoxia; ***P < 0.001 vs. hypoxia+Exo. MSCs, mesenchymal stem cells; Exo, exosomes; p-AKT/AKT, phosphorylated protein kinase B. Statistics calculated based on the results of three repetitions of each experiment

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