Fig. 7

Reuterin maintained the balance of oral pathogenic bacteria and probiotics by neutralizing LPS. a ELISA assay results demonstrated that a large amount of LPS existed in P. gingivalis sonicated extracts, and the content of LPS was significantly decreased in the mixture of P. gingivalis bacteria extract and L. reuteri sonicated extract group. b ELISA assay results showed that reuterin could neutralize LPS. c Chromatography assay results further confirmed that L. reuteri sonicated extracts contained reuterin, and reuterin maintained the balance of pathogenic bacteria and probiotics by neutralizing LPS in P. gingivalis, thus promoting wound healing (d). One-way ANOVA and Student’s t test were used to calculate statistical significance. Error bars represent SD (n = 3). *P ≤ 0.05; **P ≤ 0.01