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Fig. 10 | Stem Cell Research & Therapy

Fig. 10

From: Insulin-like growth factor-II overexpression accelerates parthenogenetic stem cell differentiation into cardiomyocytes and improves cardiac function after acute myocardial infarction in mice

Fig. 10

Cardiac function examination. At 4 weeks post-transplant (i.e., 5 weeks post-myocardial infarction, MI), ejection fraction (EF), fractional shortening (FS) (a), left ventricular end-systolic diameter (LVESd), left ventricular end-diastolic diameter (LVEDd) (b), left ventricular anterior wall thickness at end-systole (LVAWTs), and left ventricular anterior wall thickness at end-diastole (LVAWTd) (c) were determined to assess cardiac functions. *p < 0.05 vs. any other group; #p < 0.05 vs. pME 18s PSCs; Δp < 0.05 vs. pME 18s IGF-II-PSCs+IGF-II shRNA; #p < 0.05 vs. pME 18s PSCs. d–j Representative short-axis echocardiograms, with heart positioning as indicated in d. e Sham. f MI + saline. g MI + cardiomyocytes (pME 18s ESCs). h MI + cardiomyocytes (pME 18s PSCs). i MI + cardiomyocytes (pME 18s IGF-II-PSCs). j MI + cardiomyocytes (pME 18s IGF-II-PSCs+IGF-II shRNA)

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Stem Cell Research & Therapy

ISSN: 1757-6512