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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Insulin-like growth factor-II overexpression accelerates parthenogenetic stem cell differentiation into cardiomyocytes and improves cardiac function after acute myocardial infarction in mice

Fig. 8

Collagen fiber detection by Masson’s trichrome staining. a–f At 4 weeks after transplant, Masson’s trichrome staining was performed to detect collagen fibrosis (blue staining) in the injection sites of mice in Sham (a), MI + saline (b), MI + cardiomyocytes derived from ESCs (c), MI + cardiomyocytes derived from PSCs (d), MI + cardiomyocytes derived from IGF-II-PSCs (e), and MI + cardiomyocytes derived from IGF-II-PSCs+IGF-II shRNA (f) groups, respectively. Representative images at 4 weeks post-transplant are shown. Scale bars, 30 μm. g Quantification of collagen content at 4 weeks and 8 weeks post-transplant, respectively. *p < 0.05 vs. any other group; Δp < 0.05 vs. pME 18s IGF-II-PSCs+IGF-II shRNA group

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Stem Cell Research & Therapy

ISSN: 1757-6512