Fig. 5

Upregulation of miR-495 or HOXC6 silencing contributes to more cells arrested in the G1 phase and promotes cell apoptosis. The cells were treated with miR-495 mimic, miR-495 inhibitor, or si-HOXC6. a, b Cell cycle entry after different treatments examined by PI staining. c, d Cell apoptosis after different treatments detected by Annexin V/PI double staining. Data (mean ± standard deviation) were analyzed by independent sample t test. The experiment was repeated three times independently. *p < 0.05 vs. the blank group and the NC group