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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Multifaceted characterization of the signatures and efficacy of mesenchymal stem/stromal cells in acquired aplastic anemia

Fig. 7

Impaired immune inhibition of AA-MSCs. a–d Compared with HD-MSCs, AA-MSCs showed a defected capacity to inhibit the activation of CD4+ and CD8+ T cells (HD: n = 5; AA: n = 5). e, f The capacity to inhibit T cells towards Th1 (CD4+IFNγ+IL4), Th17 (CD4+IL4IL17A+), and Tc1 (CD8+IFNγ+IL4) were markedly decreased in AA-MSCs (HD: n = 5; AA: n = 5), while there was no difference in inhibiting T cells into Th2 (CD4+IFNγIL4+) and Tc2 (CD8+IFNγIL4+) between AA-MSCs and HD-MSCs

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