Fig. 9

Effective immunoregulatory capacity of UC-MSCs in AA mice. a After receiving UC-MSC transplantation, AA mice had a decreased proportion of CD4⁺ and CD8⁺ T cells in bone marrow and spleen, while, in lymph nodes, only CD8⁺ T cells was decreased (normal mice: n = 3; irrigation mice: n = 3; AA mice: n = 3; AA+MSC: n = 3). b, c UC-MSC transplantation increased the bone marrow nucleated cells in AA mice (normal mice: n = 3; irrigation mice: n = 3; AA mice: n = 3; AA+MSC: n = 3). Additionally, Th1, Tc1, and Th17 cells were significantly decreased in AA mice after infusing UC-MSCs. Meanwhile, the ration of Th1 to Th2 and Tc1 to Tc2 were also markedly decreased, while the proportions of Th2 and Tc2 were not remarkably influenced (normal mice: n = 3; irrigation mice: n = 3; AA mice: n = 3; AA+MSC: n = 3). d Intrinsic impairment of MSCs and abnormal immune status were detected in AA patients. Furthermore, UC-MSC transplantation could effectively ameliorate the hyperimmune status and restore hematopoiesis