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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: miR-765 inhibits the osteogenic differentiation of human bone marrow mesenchymal stem cells by targeting BMP6 via regulating the BMP6/Smad1/5/9 signaling pathway

Fig. 8

The osteogenic differentiation of hMSCs in which miR-765 was knocked down and at the same time as a BMP/Smad signaling inhibitor was added to block Smad1/5/9 phosphorylation. a qRT-PCR was used to compare RUNX2, OCN, and ALP expression in the different groups. b RUNX2 and OCN protein levels were assessed via Western blotting. c ALP activity was quantified. Data are expressed as means ± SD (X ± SD, n = 3). **P < 0.01 vs. shRNA+inhibitor, respectively. Note: sh: shRNA; sh+inh: sh+inhibitor

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Stem Cell Research & Therapy

ISSN: 1757-6512