Fig. 7

BMMSC-derived exosomes suppress cell proliferation and colony formation through delivering miR-144 to A549 cells. a Uptake of exosomes by A549 cells observed under a fluorescence microscope (× 1000). b Relative expression of miR-144, CCNE1, and CCNE2 detected by RT-qPCR. c Cell proliferation assessed by EdU assay (× 200). d Number of colony formation identified by colony formation assay. e Cell cycle progression measured by flow cytometry. f Relative expression of proliferation related factors tested by western blot analysis. *p < 0.05 vs. A549 cells transfected with Exo-NC mimic. ^#p < 0.05 vs. A549 cells transfected with Exo-NC inhibitor. The above measurement data were expressed as mean ± standard deviation. Comparisons between two groups were analyzed by unpaired t test. The experiment was repeated in triplicate