Fig. 8

BMMSC-derived exosomes inhibit the growth of xenografted tumors in nude mice by delivering miR-144. a Volume growth of xenograft tumors in mice. b Representative images of xenograft tumors in mice. c Weight of xenograft tumors in mice. d Expression of CCNE1, CCNE2, and KI67 in xenograft tumors assessed by IHC (× 200). e The expression of KI67 and PCNA in mice determined by western blot analysis. *p < 0.05 vs. nude mice injected with Exo-NC-agomir. The above measurement data were expressed as mean ± standard deviation. Data among multiple groups were analyzed by one-way ANOVA, followed by a Tukey post hoc test. Data among multiple groups at different time points were measured by repeated measures ANOVA, followed by Bonferroni post hoc test. N = 5