Allogeneic umbilical cord-derived mesenchymal stem cell transplantation for treating chronic obstructive pulmonary disease: a pilot clinical study

Table 3 Comparison of clinical outcomes before and after treatment

Outcome	Before treatment (N = 20)	After 1 month (N = 20)	p value*	After 3 months (N = 20)	p value*	After 6 months (N = 20)	p value*
FEV1 (%)	34.0 (24.6, 49.0)	35.0 (25.5, 55.2)	0.107	33.0 (26.5, 51.0)	0.251	33.5 (27.5, 43.0)	0.239
CRP (mg/dL)	3.3 (1.4, 5.8)	2.2 (1.4, 4.0)	0.444	2.4 (1.2, 6.1)	0.702	2.3 (1.3, 5.3)	0.284
mMRC	1.0 (0.0, 2.0)	0 (0.0, 1.0)	0.033	0 (0.0, 1.0)	0.005	0 (0.0, 1.0)	0.017
CAT	10.5 (5.8, 14.5)	6.5 (2.8, 8.8)	0.002	4.0 (2.8, 7.2)	0.001	2.0 (1.0, 7.5)	0.003
6MWT	360.0 (330.0, 420.0)	380.0 (350.0, 400.0)	0.246	360.0 (347.5, 405.0)	0.521	380.0 (355.0, 420.0)	0.250
Number of exacerbations	2 (2, 4)	–	–	–	–	0 (0, 1)	< 0.001

Note: Summary statistic is median (interquartile range). *p value was calculated based on Wilcoxon signed-rank test comparing outcomes before treatment with those at each follow-up (1, 3, and 6 months). Abbreviations: FEV1 forced expiratory volume in 1 s, CRP C-reactive protein, mMRC Modified Medical Research Council, CAT COPD assessment test, 6MWT 6-min walk test

ISSN: 1757-6512