Outcome | Before treatment (N = 20) | After 1 month (N = 20) | p value* | After 3 months (N = 20) | p value* | After 6 months (N = 20) | p value* |
---|---|---|---|---|---|---|---|
FEV1 (%) | 34.0 (24.6, 49.0) | 35.0 (25.5, 55.2) | 0.107 | 33.0 (26.5, 51.0) | 0.251 | 33.5 (27.5, 43.0) | 0.239 |
CRP (mg/dL) | 3.3 (1.4, 5.8) | 2.2 (1.4, 4.0) | 0.444 | 2.4 (1.2, 6.1) | 0.702 | 2.3 (1.3, 5.3) | 0.284 |
mMRC | 1.0 (0.0, 2.0) | 0 (0.0, 1.0) | 0.033 | 0 (0.0, 1.0) | 0.005 | 0 (0.0, 1.0) | 0.017 |
CAT | 10.5 (5.8, 14.5) | 6.5 (2.8, 8.8) | 0.002 | 4.0 (2.8, 7.2) | 0.001 | 2.0 (1.0, 7.5) | 0.003 |
6MWT | 360.0 (330.0, 420.0) | 380.0 (350.0, 400.0) | 0.246 | 360.0 (347.5, 405.0) | 0.521 | 380.0 (355.0, 420.0) | 0.250 |
Number of exacerbations | 2 (2, 4) | – | – | – | – | 0 (0, 1) | < 0.001 |