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Table 3 Comparison of clinical outcomes before and after treatment

From: Allogeneic umbilical cord-derived mesenchymal stem cell transplantation for treating chronic obstructive pulmonary disease: a pilot clinical study

OutcomeBefore treatment (N = 20)After 1 month (N = 20)p value*After 3 months (N = 20)p value*After 6 months (N = 20)p value*
FEV1 (%)34.0 (24.6, 49.0)35.0 (25.5, 55.2)0.10733.0 (26.5, 51.0)0.25133.5 (27.5, 43.0)0.239
CRP (mg/dL)3.3 (1.4, 5.8)2.2 (1.4, 4.0)0.4442.4 (1.2, 6.1)0.7022.3 (1.3, 5.3)0.284
mMRC1.0 (0.0, 2.0)0 (0.0, 1.0)0.0330 (0.0, 1.0)0.0050 (0.0, 1.0)0.017
CAT10.5 (5.8, 14.5)6.5 (2.8, 8.8)0.0024.0 (2.8, 7.2)0.0012.0 (1.0, 7.5)0.003
6MWT360.0 (330.0, 420.0)380.0 (350.0, 400.0)0.246360.0 (347.5, 405.0)0.521380.0 (355.0, 420.0)0.250
Number of exacerbations2 (2, 4)0 (0, 1)< 0.001
  1. Note: Summary statistic is median (interquartile range). *p value was calculated based on Wilcoxon signed-rank test comparing outcomes before treatment with those at each follow-up (1, 3, and 6 months). Abbreviations: FEV1 forced expiratory volume in 1 s, CRP C-reactive protein, mMRC Modified Medical Research Council, CAT COPD assessment test, 6MWT 6-min walk test