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Table 4 Comparison of clinical outcomes before and after treatment in stage C and D patients

From: Allogeneic umbilical cord-derived mesenchymal stem cell transplantation for treating chronic obstructive pulmonary disease: a pilot clinical study

OutcomeBefore treatment (N = 20)After 1 month (N = 20)p value*After 3 months (N = 20)p value*After 6 months (N = 20)p value*
FEV1 (%)
 Stage C48 (35–55)43 (34–68)0.47739 (29–65.6)0.51639 (31–50)0.922
 Stage D24.8 (23–37)32 (24–48)0.07931 (24–44)0.30930 (25–36)0.022
CRP (mg/dL)
 Stage C2.2 (1.2–3.3)1.9 (1.5–3.5)0.9141.9 (1.2–2.4)0.5471.5 (0.8–6.2)0.688
 Stage D4.2 (1.5–9)2.9 (2.2–10.4)0.3755 (1.1–6.6)0.9662.8 (2.3–5.3)0.426
mMRC
 Stage C1 (0–1)0 (0–0)0.3750 (0–0)0.1250 (0–0)0.219
 Stage D2 (1–3)1 (0–2)0.1561 (0–1)0.0310.5 (0–1)0.094
CAT
 Stage C6 (4–8)3 (2–5)0.0234 (2–6)0.0823 (1–6)0.375
 Stage D13 (11–18)8 (7–12)0.0234 (3–9)0.0012 (2–8)0.004
6MWT
 Stage C380 (350–420)380 (360–410)0.375400 (360–440)0.793400 (380–420)0.527
 Stage D350 (300–420)365 (330–390)0.539360 (330–380)0.578355 (320–400)0.509
Number of exacerbations
 Stage C2 (1–2) 0 (0–1)0.031
 Stage D2 (2–5) 0 (0–1)0.002