Allogeneic umbilical cord-derived mesenchymal stem cell transplantation for treating chronic obstructive pulmonary disease: a pilot clinical study

Table 4 Comparison of clinical outcomes before and after treatment in stage C and D patients

Outcome	Before treatment (N = 20)	After 1 month (N = 20)	p value*	After 3 months (N = 20)	p value*	After 6 months (N = 20)	p value*
FEV1 (%)
Stage C	48 (35–55)	43 (34–68)	0.477	39 (29–65.6)	0.516	39 (31–50)	0.922
Stage D	24.8 (23–37)	32 (24–48)	0.079	31 (24–44)	0.309	30 (25–36)	0.022
CRP (mg/dL)
Stage C	2.2 (1.2–3.3)	1.9 (1.5–3.5)	0.914	1.9 (1.2–2.4)	0.547	1.5 (0.8–6.2)	0.688
Stage D	4.2 (1.5–9)	2.9 (2.2–10.4)	0.375	5 (1.1–6.6)	0.966	2.8 (2.3–5.3)	0.426
mMRC
Stage C	1 (0–1)	0 (0–0)	0.375	0 (0–0)	0.125	0 (0–0)	0.219
Stage D	2 (1–3)	1 (0–2)	0.156	1 (0–1)	0.031	0.5 (0–1)	0.094
CAT
Stage C	6 (4–8)	3 (2–5)	0.023	4 (2–6)	0.082	3 (1–6)	0.375
Stage D	13 (11–18)	8 (7–12)	0.023	4 (3–9)	0.001	2 (2–8)	0.004
6MWT
Stage C	380 (350–420)	380 (360–410)	0.375	400 (360–440)	0.793	400 (380–420)	0.527
Stage D	350 (300–420)	365 (330–390)	0.539	360 (330–380)	0.578	355 (320–400)	0.509
Number of exacerbations
Stage C	2 (1–2)	–	–	–		0 (0–1)	0.031
Stage D	2 (2–5)	–	–	–		0 (0–1)	0.002

ISSN: 1757-6512