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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Electrospun fibers enhanced the paracrine signaling of mesenchymal stem cells for cartilage regeneration

Fig. 4

Inflammation modulatory (ac) and anti-apoptotic (d) effect of topographically induced CM on chondrocytes and MSCs. a Real-time PCR analysis of inflammatory-related and chondrogenic markers expression in re-differentiated chondrocyte pellet and chondrogenic MSC pellet after 7 days of inflammation treatment with 5 ng/ml and 0.5 ng/ml IL-1β, respectively. Quantification and histological analysis of cartilaginous ECM macromolecules in b re-differentiated chondrocyte pellet after 7 days of inflammation treatment with 5 ng/ml IL-1β, and c MSC pellet after 21 days of chondrogenic induction under inflammation treatment of 0.5 ng/ml IL-1β. d Apoptotic activity of chondrocytes and MSCs as determined by Caspase 3/7 activity. All data represent the mean ± SD, n = 6, from 3 independent experiments. ^ denotes p < 0.05 compared to control / negative control; # denotes p < 0.05 compared to positive control; * denotes p < 0.05 compared to TCM; ŧ denotes p < 0.05 compared to ACM. Scale bar = 100 μm

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