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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Umbilical mesenchymal stem cell-derived exosomes facilitate spinal cord functional recovery through the miR-199a-3p/145-5p-mediated NGF/TrkA signaling pathway in rats

Fig. 7

Cblb and Cbl regulated the NGF/TrkA pathway through modulation of TrkA ubiquitination. Representative images and quantitative analysis of total ubiquitinated proteins and TrkA in nontransfected PC12 cells and Cblb (a) (n = 3) and Cbl (b) (n = 3) knockdown PC12 cells. Data are represented as mean ± SD. Representative images and quantitative analysis of p-Erk and p-Akt in nontreated PC12 cells and Cblb (c) and Cbl (d) knockdown PC12 cells. Data are represented as mean ± SD. Representative images and quantitative analysis of total ubiquitinated proteins and TrkA in nontreated PC12 cells and Cblb (e)- and Cbl (f)-overexpressing PC12 cells stimulated with NGF and MG-132 (n = 3). Data are represented as mean ± SD. i Representative images and quantitative analysis of p-Erk and p-Akt in nontreated PC12 cells and Cblb (g)- and Cbl (h)-overexpressing PC12 cells stimulated with NGF and MG-132 (n = 3). Data are represented as mean ± SD. Representative coimmunoprecipitation images of TrkA and Cblb (i) and TrkA and Cbl (j) in PC12 cells. *p < 0.05; **p < 0.01; #p > 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512