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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: MicroRNA-205 mediates endothelial progenitor functions in distraction osteogenesis by targeting the transcription regulator NOTCH2

Fig. 2

MiR-205 regulates ECFC angiogenesis in vitro and ex vivo. ac The results of a Matrigel tube formation assay were assessed 6 h after plating treated ECFCs. di Transwell (df) and wound healing (gi) assays confirmed the reduced migration of ECFCs overexpressing miR-205, whereas ECFCs in which miR-205 had been knocked down exhibited enhanced migration. j, k CCK-8 assay results revealed that miR-205 overexpression significantly reduced the viability of ECFCs (j), whereas miR-205 inhibition had the opposite effect (k). ln CAM assays revealed that miR-205 overexpression significantly decreased vessel density (l), while miR-205 inhibition had the opposite effect (m). Data are means ± S.D (N.S, no significance; #P > 0.05, *P < 0.05, **P < 0.01, and ***P < 0.001; n = 3 independent experiments)

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