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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: MicroRNA-205 mediates endothelial progenitor functions in distraction osteogenesis by targeting the transcription regulator NOTCH2

Fig. 7

A schematic diagram illustrating the regulation of DO angiogenesis by miR-205. During DO, ECFCs from the peripheral blood express low levels of miR-205. The downregulation of miR-205 results in the increased expression of the transcriptional regulator NOTCH2, further augmenting the secretion of VEGF and bFGF. Increased expression of angiogenic factors by suppressing miR-205, promoting ECFC angiogenesis and thereby accelerating new bone formation and remodeling

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Stem Cell Research & Therapy

ISSN: 1757-6512