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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Exosomes derived from stem cells from apical papilla promote craniofacial soft tissue regeneration by enhancing Cdc42-mediated vascularization

Fig. 1

SCAP-Exo promoted angiogenesis to accelerate wound healing in the palatal gingiva. a Schematic indicating the experimental design for SCAP-Exo infusion in gingival wounds in the palates of mice. b Representative images and quantification of the gingival wound areas in the control and SCAP-Exo groups. Wound healing of the palatal gingiva was significantly accelerated in the SCAP-Exo group at 3 and 7 days post wounding compared to the control group. c. H&E staining was used to observe the epidermis and connective tissues formation at 7 days post wounding. Scale bar = 200 μm. Immunofluorescence staining showing significantly increased Collagen I and Fibronectin expressions in the palatal gingiva of the SCAP-Exo group at 7 days post wounding compared with the control group. Scale bar = 100 μm. d Histological views showing many newly formed blood vessels containing red blood cells in the gingival wounds of the SCAP-Exo group at 1 and 3 days post wounding compared with the control group. Scale bar = 50 μm. e Immunofluorescence staining and quantification showed that the percentage of CD31-positive area (red) in the SCAP-Exo group was higher than that in the control group at 1 and 3 days post wounding. The epidermis and connective tissues are separated by the white dotted line in the images. The slides were counterstained with DAPI (blue). Scale bar = 50 μm. n = 5 in each group. NS: P > 0.05. **P < 0.01, ***P < 0.001. Error bars: mean ± SD

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