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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Exosomes derived from stem cells from apical papilla promote craniofacial soft tissue regeneration by enhancing Cdc42-mediated vascularization

Fig. 3

SCAP-Exo-mediated cell migration contributed to HUVEC angiogenesis. a A CCK-8 assay showed that SCAP-Exo treatment had no effect on the proliferation rate of HUVECs compared with the control group. b A Ki-67 staining assay showed that the percentage of Ki-67-positive cells (red) in the SCAP-Exo group was not different from that in the control group. The slides were counterstained with DAPI (blue) and F-actin (green). Scale bar = 100 μm. c A Transwell cell migration assay showed that the motility of HUVECs was upregulated in the SCAP-Exo group compared to the control group. Scale bar = 200 μm. d Representative images of the scratch wound healing assay showing that the wound healing rate in the SCAP-Exo group was higher at 12 h and 24 h than that in the control group. Scale bar = 100 μm. n = 5 in each group. NS: P > 0.05. *P < 0.05, **P < 0.01, ***P < 0.001. Error bars: mean ± SD

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