Fig. 6

Mechanism analysis of doxorubicin-induced hUC-MSCs apoptosis. a Top 20 enriched pathways predicted by KOBAS based on the discrepancy of miRNA in Blank and Dox groups, which are related to the cytotoxicity of doxorubicin. b Top 20 enriched pathways predicted by KOBAS based on the discrepancy of miRNA in Dox and EV groups, which are related to the therapeutic potential of hP-MSC-derived extracellular vesicles for doxorubicin cytotoxicity. c The binding sites and match diagram between hsa-miR-11401 and SCOTIN are presented, and the expression of hsa-miR-11401 and SCOTIN among groups was further verified. The hsa-miR-11401 facilitated the downregulation of SCOTIN in EV groups. n = 3, ^*P < 0.05 versus Blank groups; ^#P < 0.05 versus Dox groups. d The expression of hsa-miR-11401 in extracellular vesicles showed that it can be delivered into recipient cells. n = 3,^*P < 0.05 versus MSC