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Table 1 The similarities and differences of biological characteristics in MSCs from different perinatal tissues

From: The therapeutic applications of mesenchymal stromal cells from human perinatal tissues in autoimmune diseases

Perinatal tissues Similarities Differences
Umbilical cord and compartments [16] Wharton’s jelly (WJMSCs) 1. Adherence to plastic;
2. Positive for SSEA-3, SSEA-4, Tra-1-60, and Tra-1-81;
3. Adipogenic potential and levels of telomerase activity at passage 1.
1. WJMSCs show significantly greater numbers in primary culture compared to other MSCs;
2. WJMSCs show significantly greater proliferation rates at passages 3, 5, and 10 compared to other MSCs;
3. The telomerase levels for WJMSCs were significantly greater than other MSCs at passage 10;
4. WJMSCs express significantly greater for CD29, CD44, CD73, HLA-ABC, CD24, CD108, OCT1, OCT4A, OCT4B, NANOG, and SOX2 compared to other MSCs;
5. WJMSCs and PVMSCs express significantly greater for CD146 and CD271 compared to other MSCs;
6. WJMSCs and PVMSCs express significantly less for fibroblast-related genes FAP, FSP, CD40, CD49d, and CD140b compared to other MSCs;
7. WJMSCs exhibit greater osteogenic and chondrogenic differentiation potential compared to other MSCs.
Amnion (AMSCs)
Subamnion (SAMSCs)
Perivascular (PVMSCs)
Mixed cord (UCMSCs)
Umbilical cord and membranes of the placenta [3] Umbilical cord (UCMSCs) 1. Adherence to plastic;
2. Positive for CD73, CD90, CD105, SOX2, and SSEA4
3. Negative for CD45, HLA-DR, CD34, and CD14;
4. Adipogenic, osteogenic, and chondrogenic differentiation potential.
1. CPMSCs express greater for CD106 compared to other MSCs;
2. AMMSCs, CPMSCs, and UCMSCs were of fetal origin, and DPMSCs were of maternal origin;
3. UCMSCs show shorter population doubling time than other MSCs;
4. AMMSCs exhibit better capacity in the secretion of PGE2 and TGF-β1;
5. CPMSCs secrete higher level of HGF and VCAM-1;
6. DPMSCs release higher levels of VEGF and ANG-1.
Amniotic membrane (AMMSCs)
Chorionic plate (CPMSCs)
Decidua parietalis (DPMSCs)
Umbilical cord and amnion fluid [4] Wharton’s jelly (WJMSCs) 1. Adherence to plastic;
2. Growth characteristics at passage 5;
3. Positive for the expression of CD29, CD105, HLA-ABC, and OCT4;
4. Negative for CD34 and HLA-DR;
5. Myocardial-like cells differentiation capacity in vitro.
1. AFMSCs show greater growth characteristics at passage 10 than WJMSCs.
Amnion fluid (AFMSCs)
Placenta and umbilical cord blood [7] Placenta (PMSCs) 1. Adherence to plastic;
2. Positive for the expression of CD44, CD73, CD90, CD105, and KLF4;
3. Negative for CD14, CD34, and CD45;
4. Growth characteristics;
5. Adipogenic, osteogenic, and chondrogenic differentiation potential;
6. Immunomodulatory effects.
1. PMSCs are positive for the expression of NANOG;
2. UCBMSCs are positive for expression of MYC.
Umbilical cord blood (UCBMSCs)