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Table 2 Characteristics of included studies in the meta-analysis (no MSCs group)

From: Mesenchymal stromal cells as prophylaxis for graft-versus-host disease in haplo-identical hematopoietic stem cell transplantation recipients with severe aplastic anemia?—a systematic review and meta-analysis

Author (publication year) Study design Recruitment period Number of patients Median age Sex (M/F) Type Conditioning regimen GVHD prophylaxis Interval from diagnosis to treatment (M) Neutrophil recovery (d) Platelet engraftment MSCs originals NOS score
Zhang YY [56] (2020) Single-arm study January 2013-Septemper 2018 35 43 (40–54) 23/11 SAA/VSAA (19/16) BU + CY + ATG CsA + MMF + MTX NA 13 (9–21) 17 (10–102) NA 6
Ma YR [55] (2020) Single-arm study NA 199 NA 106/93 NA BU + CY + ATG CsA + MMF + MTX NA NA NA NA 6
Liu LM [54] (2020) Single-arm study Septemper 2010-Septemper 2018 16 32 (8–55) 9/7 NA ATG + rituximab NA NA 11 (9–20) 21 (13–112) NA 6
Yang SW [22] (2019) Single-arm study NA 32 NA 21/11 NA NA NA NA NA NA NA 6
Xu LP5 [53] (2019) Single-arm study 2006–2018 392 NA 223/167 NA BU + CY + ATG CsA + MMF + MTX NA 12 (9–31) 14 (5–180) NA 6
Hyery Kim [52] (2019) Single-arm study 2008–2017 32 12.7 (1.4–21.7) 22/10 SAA/VSAA (20/12) FLU, CY, ATG ± TBI CsA + MMF 5.2 (1.2–106.8) 10 (9–30) 15.5 (13–60) NA 5
Lu Y [51] (2018) Single-arm study Septemper 2012-Septemper 2016 41 13 (4–42) 25/16 SAA/VSAA(28/13) FLU, CY, ATG CsA + MMF + MTX 25 (6–45) 14 (10–21) 13 (3–56) NA 6
Sung-Eun Lee [24] (2018) Single-arm study June 2012-December 2016 34 31.5 (17–59) 20/14 SAA/VSAA (11/23) ATG + TBI + FLU CsA + MTX NA 12 (11–12) 14 (5–86) NA 5
Cheng YF [50] (2018) Single-arm study December 2007-Septemper 2016 28 NA NA NA NA NA 2.75 (1–8) 12 (10–21) NA NA 6
Cao LQ [49] (2018) Single-arm study January 2006-December 2016 131 16 (2–45) 70/61 NA NA NA NA 12 (10–31) 16 (7–276) NA 5
Zhang P [48] (2017) Single-arm study June 2014-December 2015 8 14 (5–26) 5/3 NA FLU, CY, ALG/TBI CsA + MMF + MTX NA 14.8 (11–20) 15.0 (11–21) NA 6
Zhang Y [47] (2017) Single-arm study June 2010-December 2014 18 NA NA NA NA NA NA 16 (12–26) 20 (17–35) NA 5
Pei XY [46] (2017) Single-arm study January 2008-December 2015 81 14 (3–45) 50/31 SAA/VSAA (63/18) NA NA NA 12 (10–22) 15 (7–150) NA 6
Sarita Rani Jaiswal [45] (2017) Single-arm study January 2015-May 2016 20 NA NA NA FLU, CY, ATG, melphalan PTCy + sirolimus + CsA + MMF (abatacept) NA NA NA NA 5
Amy E. DeZern [44](2017) Single-arm study July 2011-August 2016 13 33 (11–69) 9/5 NA FLU, CY, ATG ± TBI PTCy+MMF + FK506 NA 19 (16–27) 28 (22–108) NA 5
Zhu H [43] (2016) Single-arm study July 2002-November 2013 38 NA 12/24 SAA/VSAA (8/28) FLU, CY, ATG ± TBI/BU CsA + methotrexate (MTX) (n = 12) CsA + MTX + mycophenolate mofetil (MMF) (n = 22) MTX + tacrolimus (n = 4) NA NA NA NA 6
Liu L [42] (2016) Single-arm study July 2005-December 2013 26 26 (10–54) 15/11 SAA/VSAA/(16/6) NA NA NA 12 (6–28) 19 (12–330) NA 5
Ho Joon Im [41] (2015) Single-arm study NA 21 14 (3–21) NA NA FLU, CY, ATG ± TBI NA NA NA NA NA 6
Esteves I [25] (2015) Single-arm study July 2010-August 2014 16 17 (5–39) 11/5 NA CY + FLU+ TBI, FLU + ATG (2) MMF, CsA, Cy NA 19 (16–29) 21 (20–29) NA 6
Gao L [40] (2014) Single-arm study June 2007-December 2010 26 25.4 (18–41) NA SAA/VSAA (16/10) FLU, CY, ATG CsA + MMF + MTX + ATG NA 13 (11–19) 13 (10–21) NA 5
Jennifer Clay [39] (2014) Single-arm study NA 8 NA NA NA CY + FLU + TBI MMF + FLU + PTCY NA 18.5 (16–23) 26 (21–27) NA 5
  1. Abbreviations: SAA severe aplastic anemia, VSAA very severe aplastic anemia, ATG antithymoglobulin, CsA cyclosporin A, MSCs bone marrow-mesenchymal stem cells, haplo-HSCT haplo-identical hematopoietic stem cell transplantation, BU busulfan, Cy cyclophosphamide, MMF mycophenolate mofetil, FLU fludarabine, MTX methotrexate, GVHD graft-versus-host disease, TBI total body irradiation
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Stem Cell Research & Therapy

ISSN: 1757-6512