Table 2 Score sheet
From: Intrapancreatic MSC transplantation facilitates pancreatic islet regeneration
Mouse identification: | Date: | ||||||||
Time: | |||||||||
1. Body weight | Score | ||||||||
Based on starting weight [] | |||||||||
Based on the weight of the control group [] | |||||||||
Uninfluenced or rise | 0 | ||||||||
Reduction, but < 10% | 1 | ||||||||
Reduction > 10% | 2 | ||||||||
Reduction > 20% | 3 | ||||||||
2. General condition | |||||||||
Shiny eyes, body openings and skin clean | 0 | ||||||||
Cloudy eyes, increased muscle tone, more visible breathing | 1 | ||||||||
Eyes sunken dull, sticky body openings, increased breathing | 2 | ||||||||
Abnormal posture, animal feels cold, eyes closed, cramps, paralysis, breathing sounds, bluish mucous membranes, diarrhoea | 3 | ||||||||
3. Spontaneous behaviour | |||||||||
Attentive, curious, straightening, quick movements | 0 | ||||||||
Decreased reactions, movement reduced, restricted or excessive activity | 1 | ||||||||
Partial separation from the group, movement reduced, pain when walking | 2 | ||||||||
Apathetic, no reaction or aggressiveness in handling, severely restricted movement, isolation, drag forward. | 3 | ||||||||
4. Trial-specific criteria | |||||||||
Blood sugar < 200 mg/dl | 0 | ||||||||
Blood sugar increased (> 200 mg/dl) | 1 | ||||||||
Blood sugar increased (> 400 mg/dl) | 2 | ||||||||
Blood sugar reduced (< 60 mg/dl) At the same time, weight loss | 3 | ||||||||
5. Other termination criteria | |||||||||
Self-injury (e.g. excessive itching) | 3 | ||||||||
Total score | |||||||||