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Table 2 Score sheet

From: Intrapancreatic MSC transplantation facilitates pancreatic islet regeneration

Mouse identification: Date:         
  Time:         
1. Body weight Score         
 Based on starting weight []         
 Based on the weight of the control group []
 Uninfluenced or rise 0         
 Reduction, but < 10% 1
 Reduction > 10% 2
 Reduction > 20% 3
2. General condition          
 Shiny eyes, body openings and skin clean 0         
 Cloudy eyes, increased muscle tone, more visible breathing 1
 Eyes sunken dull, sticky body openings, increased breathing 2
 Abnormal posture, animal feels cold, eyes closed, cramps, paralysis, breathing sounds, bluish mucous membranes, diarrhoea 3
3. Spontaneous behaviour          
 Attentive, curious, straightening, quick movements 0         
 Decreased reactions, movement reduced, restricted or excessive activity 1
 Partial separation from the group, movement reduced, pain when walking 2
 Apathetic, no reaction or aggressiveness in handling, severely restricted movement, isolation, drag forward. 3
4. Trial-specific criteria          
 Blood sugar < 200 mg/dl 0         
 Blood sugar increased (> 200 mg/dl) 1
 Blood sugar increased (> 400 mg/dl) 2
 Blood sugar reduced (< 60 mg/dl)
At the same time, weight loss
3
5. Other termination criteria  
 Self-injury (e.g. excessive itching) 3
Total score