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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Pluripotent stem cell-induced skeletal muscle progenitor cells with givinostat promote myoangiogenesis and restore dystrophin in injured Duchenne dystrophic muscle

Fig. 6

Givi-MPC repopulated the muscle stem cell pool. a Muscle cells positive for Pax7 (red) and human laminA/C (green) cell under the basal lamina from Mdx/SCID mice after 1 M post-Givi-MPC transplantation. Bar = 20 μm. The boxed area is zoomed below. b Schematic outline of reinjury experiment. c 1 M after reinjury, the expression of dystrophin in Givi-MPC-treated TA muscle tissue. Bar = 50 μm. d Representative HE-stained images of Givi-MPC-treated TA muscle tissue and contralateral PBS-treated TA muscle tissue. Bar = 50 μm. e Representative images of tissue stained with Sirius red after reinjury. Bar = 50 μm. f Quantification of muscle fiber fibrosis in TA muscle treated with PBS and Givi-MPC after reinjury. n = 4

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