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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Pluripotent stem cell-induced skeletal muscle progenitor cells with givinostat promote myoangiogenesis and restore dystrophin in injured Duchenne dystrophic muscle

Fig. 7

Extracellular vesicles derived from Givi-MPC promoted angiogenesis. a Representative images of CD31 (red) and laminin (green) staining in Mdx/SCID mice treated with MPC 1 M post-injury. Bar = 50 μm. The boxed area is shown at high magnification. b Quantification of capillary density (CD31-positive capillaries). c Representative images of tube formation by human aortic endothelial cells (HAECs) following EVs treatment from human myoblasts, or control-MPC or Givi-MPC (1 μg/well, 24-well plate). HAECs were labeled with Calcein AM (green). Bar = 500 μm. d Tube formation assay. Average tube length was analyzed from 3 biological repeated experiments. Heatmap showing upregulation of miRNAs in EVs derived from Givi-MPC compared to EV human myoblasts (e) and control-MPC (f)

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Stem Cell Research & Therapy

ISSN: 1757-6512